LB1037 Aberrant regulation of protein translation controlled by eukaryotic initiation factor 4F (eIF4F) in the pathogenesis of hidradenitis suppurativa (HS) and associated cutaneous squamous cell carcinoma (cSCC)

Abstract

HS is a chronic inflammatory skin disorder and often associated with neoplastic growth of cSSC. Between 1%-3.2% of HS patients develop cSCC, however, the molecular pathogenesis of this disease remains undefined. Here, we demonstrate the pathogenic role for the 5’cap-binding protein complex eIF4F in HS and lesion-associated cSSC. This complex is composed of the scaffold protein eIF4G, the cap-binding protein eIF4E and a DEAD-box helicase eIF4A1. Employing confocal microscopy, we observed elevated expression of eIF4E, eIF4G, and eIF4A1 in HS skin that co-localized in hyperproliferative keratinocytes and associated with enhanced eIF4E translation targets, Cyclin D1 and c-Myc.