Abstract
The pathogenesis of striae gravidarum (SG) remains unclear. We obtained samples of early, abdominal SG emerging within 4-45 days and adjacent, involved skin (control) in pregnant women (n=8). We performed second harmonic generation (SHG) imaging coupled with multiphoton microscopy, and transcriptomic profiling (RNA-Seq). In SG, SHG imaging revealed that dermal type I collagen bundles appeared disorganized and separated. In the “spaces” between bundles, there were thin, loosely packed, wavy collagen fibrils, which were 47% less dense and 56% thinner (cross-sectional width 12.6±1.3 μm [mean±SEM]) than intact collagen bundles (28.3±2.0 μm).
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