Abstract
To overcome inherent drawbacks associated with human-derived platelet-rich plasma (PRP) and exosome therapeutics in the treatment of hair thinning and other dermatological conditions, plant exosome-like nanovesicles were derived from Ashwagandha (Withania somnifera) seeds (Ash-PELNs) to test their regenerative capacity. Prior Ash-PELN studies indicate topical human safety, tolerability and anagen active hair growth prolongation. The regenerative capacity of Ash-PELNs was evaluated in vitro by cellular proliferation, angiogenesis, and growth factor stimulation measures.
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