Abstract
Eccrine sweat glands are the predominant ectodermal appendage of human skin and are essential in human thermoregulation. Despite their importance, the developmental program and the cellular interactions that drive eccrine gland formation are poorly understood. In mouse volar skin, to which eccrine glands are restricted in this species, the expression of the transcription factor Engrailed-1 (En1) in basal ectoderm is required for the specification of eccrine placodes, while in humans, the upregulation of EN1 in a hallmark of eccrine-forming skin.
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