Abstract
Cold atmospheric plasma (CAP) has been found effective in tumor treatment and promises to be adjuvant agents for various tumors. In melanoma, it has been reported that CAP can alter metabolism, senescence, migration, apoptosis and autophagy, and improve efficacy of chemotherapeutic agents. Current first-line therapeutic agents of advanced melanoma are immune checkpoint blockade and BRAF inhibitor (BRAFi)/MEK inhibitor (MEKi). These agents have definite effects with fatal limitation, drug resistance.
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