LB011-SUN PLASMA ANTI-MÜLLERIAN HORMONE (AMH) LEVELS CORRELATE AND PREDICT THE RESPONSE TO LIFESTYLE INTERVENTION IN POLYCYSTIC OVARIAN SYNDROME

Abstract

Rationale: Polycystic Ovary Syndrome (PCOS) has a prevalence of 6 10% of the women in fertile age. The disease criteria constituting diagnosis and symptoms include menstrual dysfunction, hirsutism, acne and obesity. PCOS treatment in our study aims at lifestyle interventions such as dietary management and physical exercise. Women with PCOS have increased serum levels of Anti-Mullerian Hormone (AMH) compared with controls. Methods: 57 obese women with PCOS were randomized into three groups either to dietary management with low calorie diet, physical exercise or in combination with diet and exercise. Serum AMH as well as ovulatory and metabolic variables were assessed at baseline and after the four months study period. Results: Lower baseline AMH predicts the menstrual response to lifestyle intervention (p = 0.029, OR 0.98, 95%CI 0.96 1.00). The mean AMH level before the intervention was 66.2±42.0 pmol/L for the total study population with no statistical difference between the three groups (p = 0.86). There was a significant overall change in AMH in response to lifestyle intervention (p < 0.05). In the diet group, there was a decrease in AMH (p < 0.01) but not in the exercise group (p = 0.48) or in the combined group (p = 0.32). Levels of AMH were significantly lower in the diet group than in the exercise group after intervention (p < 0.01). Conclusion: Our findings support that the low calorie diet and the weight reduction for obese women with PCOS affects the AMH and the use of AMH as a biomarker of the severity of PCOS and a predictor of response to lifestyle intervention in PCOS patients, and a direct link between AMH and the severity of PCOS is suggested.