LB-S&T-31 DYNAMIC PENILE PEAK SYSTOLIC VELOCITY IS RELATED TO MAJOR ADVERSE CARDIOVASCULAR EVENTS IN HYPERTENSIVE PATIENTS WITH ERECTILE DYSFUNCTION

Abstract

You have accessJournal of UrologyLate-Breaking S&T Poster1 Apr 2016LB-S&T-31 DYNAMIC PENILE PEAK SYSTOLIC VELOCITY IS RELATED TO MAJOR ADVERSE CARDIOVASCULAR EVENTS IN HYPERTENSIVE PATIENTS WITH ERECTILE DYSFUNCTION Zisis Kratiras, Konstantinos Makarounis, Nikolaos Ioakeimidis, Philippos Kapogiannis, Vasilios Spapis, Athanasios Angelis, Charalambos Thomas, Charalambos Vlachopoulos, Dimitrios Tousoulis, and Charalambos Fasoulakis Zisis KratirasZisis Kratiras More articles by this author , Konstantinos MakarounisKonstantinos Makarounis More articles by this author , Nikolaos IoakeimidisNikolaos Ioakeimidis More articles by this author , Philippos KapogiannisPhilippos Kapogiannis More articles by this author , Vasilios SpapisVasilios Spapis More articles by this author , Athanasios AngelisAthanasios Angelis More articles by this author , Charalambos ThomasCharalambos Thomas More articles by this author , Charalambos VlachopoulosCharalambos Vlachopoulos More articles by this author , Dimitrios TousoulisDimitrios Tousoulis More articles by this author , and Charalambos FasoulakisCharalambos Fasoulakis More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2016.03.112AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Hypertension is associated with abnormal penile blood flow. Impaired cavernous vasculature, particularly decreased penile Dynamic Peak Systolic Velocity (D-PSV) has been related to ″silent″ cardiovascular disease. The purpose of this study was to determine the correlation between D-PSV and Major Adverse Cardiovascular Events (MACEs) in middle-aged hypertensive men suffering from Erectile Dysfunction (ED). METHODS 298 consecutive hypertensive males (mean age 55 ± 9 years old) suffering from ED were prospectively evaluated. Patients with known cardiovascular disease, diabetes, secondary hypertension, renal insufficiency, acute/chronic inflammatory disease, malignancy and overt endocrine disease were excluded. Morning blood samples were taken from each patient in order to determine total testosterone, glucose, cholesterol, triglycerides and high sensitivity C reactive protein. All subjects underwent a penile color Doppler ultrasound and the incidence of MACEs was the main endpoint of our study. RESULTS During the mean follow-up period of 4.9 years, a total of 22 (7%) MACE occurred. The whole population was divided into tertiles according to the D-PSV value (low tertile <25 cm/s; middle tertile 25-35 cm/s; high tertile >35 cm/s). According to Kaplan Meier survival curve, penile D-PSV was significantly associated with MACE and the difference between the high and low D-PSV tertiles were statistically significant (Mantel log-rank test: 8.37; P<0.01) {Figure 1}. In multivariate Cox models, subjects with low D-PSV had a significantly increased risk for MACE after adjustment for age, systolic BP and other important confounders {Table 1}. CONCLUSIONS Low D-PSV is associated with increased risk for a MACE in hypertensive non-diabetic males without ″known″ cardiovascular disease and this relation is independent of age, hypertension severity and related testosterone levels. © 2016FiguresReferencesRelatedDetails Volume 195Issue 4SApril 2016Page: e349 Advertisement Copyright & Permissions© 2016MetricsAuthor Information Zisis Kratiras More articles by this author Konstantinos Makarounis More articles by this author Nikolaos Ioakeimidis More articles by this author Philippos Kapogiannis More articles by this author Vasilios Spapis More articles by this author Athanasios Angelis More articles by this author Charalambos Thomas More articles by this author Charalambos Vlachopoulos More articles by this author Dimitrios Tousoulis More articles by this author Charalambos Fasoulakis More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...