LB-S&T-13 STATISTICAL AND BIOLOGICAL EVIDENCES OF LINK BETWEEN HELICOBACTER PYLORI EXPOSURE AND PROSTATE INFLAMMATORY DISEASES

Abstract

You have accessJournal of UrologyLate-Breaking S&T Poster1 Apr 2016LB-S&T-13 STATISTICAL AND BIOLOGICAL EVIDENCES OF LINK BETWEEN HELICOBACTER PYLORI EXPOSURE AND PROSTATE INFLAMMATORY DISEASES Dong-Ru Ho, Chih-Shou Chen, Wei-Yu Lin, Yun-Ching Huang, Jian-Hui Lin, Kuo-Tsai Huang, and Pey-Jium Chang Dong-Ru HoDong-Ru Ho More articles by this author , Chih-Shou ChenChih-Shou Chen More articles by this author , Wei-Yu LinWei-Yu Lin More articles by this author , Yun-Ching HuangYun-Ching Huang More articles by this author , Jian-Hui LinJian-Hui Lin More articles by this author , Kuo-Tsai HuangKuo-Tsai Huang More articles by this author , and Pey-Jium ChangPey-Jium Chang More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2016.03.094AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Previous studies had implied that Helicobacter pylori (H.pylori) exposure may initiate systemic inflammation and result in prostate diseases. We designed this retrospective cohort study utilizing a population-based dataset to examine the association of Helicobacter pylori (H. pylori) infection with prostate diseases. A simple non-bacterial prostatitis rat model was designed to evaluate effect of H.pylori protein exposure on arising of prostatitis. METHODS In the statistical part, we used data sourced from the Taiwan Longitudinal Health Insurance Database. The cases comprised 12,439 subjects with H. pylori infection and 12,439 randomly matched subjects without H. pylori infection as controls. We used a conditional logistic regression to calculate the odds ratio (OR) for benign prostate disease (BPD) between subjects with and without H. pylori infection. In animal study, subcutaneous dorsal H. pylori protein extract injection in time sequential manner was used to induce chronic reaction. Systemic and prostate inflammation were evaluated by checking splenic tumor necrosis factor alpha (TNF-a), interleukin-1 beta (IL-1b), and prostatic nuclear factor-kappa B (NF-kB) respectively. Prostate was stained to confirm the location of these responses. RESULTS Of the 24878 sampled subjects, 3688 (14.8%) had developed BPD after the index date; BPD was found in 2008 (16.1%) cases and 1680 (13.5%) controls (p<0.001). Regression analysis revealed, the OR for BPD among cases was 1.215 (95% CI = 1.130-1.306, p<0.001) after adjusting for diabetes, hypertension, hyperlipidemia, coronary artery disease, urinary tract infection, and urolithiasis. In rats with protein extract injection, increased tactile hypersensitivity in scrotal base was found 15 days after injection. There were Increased TNF-a and IL-1b. Prostate inflammation was also confirmed by NF-kb and Caspase 1 staining, which was compatible with physiological changes in rats. CONCLUSIONS There may be some link between H.pylori protein exposure and prostate inflammation. Our analysis may be only a part of the whole picture. Local prostatic inflammation may be induced by distant antigen-related systemic response. © 2016FiguresReferencesRelatedDetails Volume 195Issue 4SApril 2016Page: e340-e341 Advertisement Copyright & Permissions© 2016MetricsAuthor Information Dong-Ru Ho More articles by this author Chih-Shou Chen More articles by this author Wei-Yu Lin More articles by this author Yun-Ching Huang More articles by this author Jian-Hui Lin More articles by this author Kuo-Tsai Huang More articles by this author Pey-Jium Chang More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...