Abstract
The aim of this study was to investigate whether serum soluble lectin-like oxidized low-density lipoprotein receptor-1 (sLOX-1), which mediates initiation and progression of atherosclerosis in endothelial cells, could be a novel marker for peripheral artery disease (PAD) in patients with type 2 diabetes.We evaluated relationships of serum sLOX-1 to ankle–brachial index (ABI) and examined the association of serum sLOX-1 with PAD in 410 patients with type 2 diabetes.Serum sLOX-1 was inversely correlated with ABI (r = − 0.197, P < 0.0001). Stepwise regression analysis demonstrated that serum sLOX-1 (β = − 0.168, F = 5.571, P < 0.05) was independently associated with ABI, and multiple logistic regression analysis demonstrated that serum sLOX-1 (16.254 (1.237–213.651), P = 0.0339) was independently associated with PAD.Serum sLOX-1 is associated with ABI and it could be a novel marker for PAD in patients with type 2 diabetes.
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