LB.01.15] DECREASE OF CARDIOVASCULAR RISK IN HYPERTENSIVE AND HYPERTENSIVE-DIABETIC PATIENTS AFTER A PROGRAM OF PHARMACEUTICAL INTERVENTION

Abstract

Objective: To determine the effectiveness of a pharmaceutical care plan by reducing CVR in a sample with moderate-high or high CVR in a rural community pharmacy. Design and method: Clinical trial with an intervention group and a control group with a previous non-probabilistic sampling of consecutive cases followed by a probabilistic one by simple randomization in 2 groups stratified by age and sex. Were included patients who came to the pharmacy office with cardiovascular prescriptions and moderate-high or high CVR. The pharmaceutical care plan includes group talk about CVR and an individual strategy through a plan of modification of lifestyles, all through interviews and follow-ups allowing to detect non-compliances, safety problems or problems of effectiveness. The Framingham score was determined and, on the other hand, CVR in percentage at the beginning and at the end of the study, calculated with the D ’Agostino formula. Results: Comparison of Framingham (%) CVR and score between groups at baseline in hypertensive patients with and without diabetes is presented. No comparison showed statistically significant differences. We also present a comparison of Framingham VR (%) and score between groups at the end of follow-up in hypertensive patients with and without diabetes. There was a decrease in CVR and score in each of the variables, with a significant reduction in the mean of the Framingham score in hypertensive patients with diabetes. The mean score decreased 2.3 points (17.8 vs 20.1, P < 0.05) in the range of 23.9% and 26.5% probability of having a cardiovascular event in the next 10 years. We present the measure of the percentage change in the CVR or its score at the end of the study, between groups in hypertensive patients with and without diabetes. The mean score decreased by 10.1% (-3.7% vs +6.4%, p < 0.05) in diabetic hypertensive patients, a similar tendency presents the CVR data with a tendency to significance. Conclusions: The application of a pharmaceutical care plan has a positive influence on the decrease of the CVR in the hypertensive population with and without diabetes, showing a statistically significant decrease in the diabetic-hypertensive population.