Abstract
Layered double hydroxides, shortly LDH, are commonly used in medical applications, particularly in human therapies for their abilities to sorb and/or entrap, and then release active drugs. In this work, we synthesized several original LDH nanocarriers that strictly host antibiotics into their interlayer space and can be used for antimicrobial purpose. Combining Infrared and XRD analyses, we evidenced the total antibiotic intercalation within the nanocarriers. Our results also highlighted the high stability of synthesized LDH in solution and particularly in rich nutritive medium used as surrogate for biological media. According to our microbial toxicity assays, we demonstrated that the antibacterial activity of LDH was purely bacteriostatic in absence of hosted biocides molecules. Besides, we observed an additive effect in LDH antibacterial activity when antibiotics were hosted and released from these nanocarriers. The use of LDH as nanocarriers for the delivery of antimicrobial agents should be of major interest in antimicrobial purpose as they offer the possibility to be recycled and reloaded with antimicrobial agents after total release.
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