Abstract
Biocompatible clay materials have attracted particular attention as the efficient drug delivery systems (DDS). In this article, we review developments in the use of layered double hydroxides (LDHs) for controlled drug release and delivery. We show how advances in the ability to synthesize intercalated structures have a significant influence on the development of new applications of these materials. We also show how modification and/or functionalization can lead to new biotechnological and biomedical applications. This review highlights the most recent progresses in research on LDH-based controlled drug delivery systems, focusing mainly on: (i) DDS with cardiovascular drugs as guests; (ii) DDS with anti-inflammatory drugs as guests; and (iii) DDS with anti-cancer drugs as guests. Finally, future prospects for LDH-based drug carriers are also discussed.
Highlights
Some layered double hydroxides (LDHs) occur naturally, recent years have seen an explosive growth in the controlled synthesis of new LDH materials and in this review we focus on the prospects of these synthetic LDHs for use in clinical therapy
The results showed that the release of the drug from the supramolecular LDH materials is a slow process, especially in the case of Mg/Al intercalated materials, suggesting that these drug-inorganic hybrids can be used as an effective drug delivery system
LDH-based drug carrier systems have been employed as drug delivery system (DDS) and shown potential practical applications for the controlled release of a variety of pharmaceutical active agents
Summary
Drug delivery systems (DDS) are designed to either alter the pharmacokinetics and biodistribution of their associated drugs, or to function as drug reservoirs (i.e., as sustained release systems)—or. It is worth mentioning that the pioneering works of Choy’ group have led to a rapid development in the research on both varied LDHs/polymers/anions hybrid systems and pharmaceutical applications of LDHs especially involving the biocompatibility and toxicity of LDHs and anti-cancer drugs intercalated LDH materials All these positive attributes make drug–LDH nanocomposite an applicable platform in vivo for further evaluation. LDHs are synthesized, and have several other attractive features such as the tunability of layer charge density and particle size, good biocompatibility, low toxicity, and a so-called “structural memory effect” Based on these properties, LDHs have been widely exploited to create new materials for applications in catalysis [26], drug delivery [27,28], and environmental remediation [29]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
