Abstract

The layer-by-layer technique was exploited to adjust the magnitude of the host–guest interactions between adamantane and cyclodextrin. The effect depends on numerous complex and changeable growth profiles of the films and the number of bilayers. These composite films of mesoporous silica nanoparticles and hyaluronic acid–cyclodextrin(HA-CD) were constructed to load the fluorescent dyes and peptides. The release rates of these molecules would decrease with an increase in the number of layers. A laser scanning confocal microscope was utilized to obtain the diffusion coefficient of fluorescein isothiocyanate. Hybrid films could be applied to increase the loading of different kinds of molecules and could also be integrated into the lamination to delay the rate of release.

Highlights

  • The layer-by-layer (LbL) technique is a facile method to prepare hybrid films with a structural control, at the nanoscopic scale [1,2,3,4]

  • A facile strategy to construct laminated multilayer films embedded with mesoporous silica nanoparticles has been developed

  • Mesoporous silica nanoparticles acted as the general fluorescent probe and the peptide containers

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Summary

Introduction

The layer-by-layer (LbL) technique is a facile method to prepare hybrid films with a structural control, at the nanoscopic scale [1,2,3,4]. It is among the most widely used techniques to construct the organic–inorganic hybrid films [5,6,7]. Hybrid films which incorporate inorganic nanoparticles are prepared either by using a covalent cross-linkage or by the non-covalent interactions between these polymers and inorganic nanoparticles [13,14,15]. Improvements in the diffusion of fluorescent molecules are valuable and could provide an insight into the host–guest interactions in diverse, advanced functional materials [32,33,34]

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