Abstract
Layered double hydroxides (LDHs), also known as hydrotalcite-like anionic clays, have been proposed as a potential biocompatible carrier for gene and drug molecules. Gene molecules (such as DNA and siRNA molecules) were either typically intercalated into the layer galleries of powdered LDH nanoparticles, or encapsulated within spherical LDH nanoshells. Herein, we describe a preparation of the (DNA/LDH)n ultrathin films via layer-by-layer (LbL) assembly between DNA and exfoliated LDHs nanosheets prepared by a scalable method. Atomic force microscopic observations show that the DNA/LDH monolayer consists of the linearly aligned DNA and the supported LDH nanosheets. Results of UV–vis spectra and XRD patterns reveal the homogenous LbL assembly of the resulting (DNA/LDH)n multiple thin films. Our results may initiate preparation of the integrated bio-LDH films with possible application in film sensors.
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