Abstract
BackgroundConstipation is a very common health problem in the world. Intake of sufficient amount of dietary fibers is a cornerstone in the prevention and treatment of constipation. As a traditional medicine, flaxseed has been used to treat constipation for centuries, but the controlled trials are rare. The purpose of the present study was to assess that whether partially defatted flaxseed meal (PDFM) has the potential role to facilitate fecal output in normal and experimental constipated mice.MethodsAfter supplemented with 2.5%, 5% and 10% (w/w) PDFM (L-, M- and H -PDFM) for 14 days, the constipation models of mice were induced by atropine-diphenoxylate. The small intestinal transit rates, start time of defecation, amount of defecation and wet weight of feces were researched in normal and constipation model mice.ResultsM- and H-PDFM significantly increase small intestinal transit rates in constipation model mice. All dose of PDFM markedly shortened the start time of defecation and M- and H-PDFM significantly increase stool frequency and weight in both normal and constipation model mice.ConclusionsPDFM may be a useful laxative to facilitate fecal output in normal and constipation conditions.
Highlights
Constipation is a very common health problem in the world
Effect of partially defatted flaxseed meal (PDFM) on small intestinal transit rate in normal mice The effect of PDFM on the small intestinal transit rate was evaluated by charcoal powder propelling ratio
Effect of PDFM on fecal output character in normal mice The effect of PDFM on fecal output character in normal mice is shown in Figure 1a, b and 1c
Summary
Constipation is a very common health problem in the world. Constipation is a worldwide public health problem in both developed and developing countries. Constipation is defined as infrequent or difficult passage of stool. It significantly affects the quality of life because constipation can cause discomfort and restlessness and abdominal distension, vomiting, restlessness, gut obstruction, and perforation and even is associated with fatal pulmonary embolism [1]. A lot of drugs have been approved for the treatment of constipation and most of them are laxatives. These drugs are not so ideal in clinical use because of their potentially
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