Abstract
BackgroundThe present study described the phytochemical profile of Lavandula stoechas essential oils, collected in the area of Ain-Draham (North-West of Tunisia), as well as their protective effects against alloxan-induced diabetes and oxidative stress in rat.MethodsEssential oils samples were obtained from the aerial parts of the plant by hydrodistillation and analyzed by GC–MS. Rats were divided into four groups: Healthy Control (HC); Diabetic Control (DC); Healthy + Essential Oils (H + EO) and Diabetic + Essential Oils (D + EO).Antidiabetic and antioxidant activities were evaluated after subacute intraperitoneally injection of Lavandula stoechas essential oils (50 mg/kg b.w., i.p.) to rats during 15 days.ResultsThe principal compounds detected are: D-Fenchone (29.28%), α-pinene (23.18%), Camphor (15.97%), Camphene (7.83%), Eucapur (3.29%), Limonene, (2.71%) Linalool, (2.01%) Endobornyl Acetate (1.03%). The essential oils also contained smaller percentages of Tricyclene, Cymene, Delta-Cadinene, Selina-3,7(11)-diene. Furthermore, we found that Lavandula stoechas essential oils significantly protected against the increase of blood glucose as well as the decrease of antioxidant enzyme activities induced by aloxan treatment. Subacute essential oils treatment induced a decrease of lipoperoxidation as well as an increase of antioxidant enzyme activities.ConclusionsThese findings suggested that lavandula stoechas essential oils protected against diabetes and oxidative stress induced by alloxan treatment. These effects are in partly due to its potent antioxidant properties.
Highlights
The Mediterranean diet has been credited with many beneficial effects in the prevention and treatment of cardiovascular diseases [1], including improvement of lipid profiles, reduction in blood pressure, insulin resistance, blood glucose concentration and inflammatory biomarkers [2]
We studied the protective effect of the lavandula stoechas essential oils against diabetes and oxidative stress induced by alloxan treatment in rat
Chemicals Alloxan monohydrate, 5,5-dithio bis(2-nitrobenzoic acid) (DTNB), trichloroacetic acid (TCA), KOH, ethanol, ether, bovine serum albumin, orthophosphoric acid 85%, and NaCl were obtained from Sigma-Aldrich Co. (Germany)
Summary
The Mediterranean diet has been credited with many beneficial effects in the prevention and treatment of cardiovascular diseases [1], including improvement of lipid profiles, reduction in blood pressure, insulin resistance, blood glucose concentration and inflammatory biomarkers [2]. Free radicals and reactive oxygen species (ROS) are well known as inducers of cellular and tissue pathogenesis leading to several human diseases such as cancer, inflammatory disorders, atherosclerosis and cardiovascular cardiovascular disease events is to target the hyperlipidemia and oxidative stress by diet and/or drug intervention. Lavender (Lavandula stoechas L.) is a medicinal plant largely used in the Tunisian traditional medicine. This plant is known to protect against headaches, depression and diabetes [13,14]. The present study described the phytochemical profile of Lavandula stoechas essential oils, collected in the area of Ain-Draham (North-West of Tunisia), as well as their protective effects against alloxan-induced diabetes and oxidative stress in rat
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