​Laurocerasus officinalis Roem: Biochemical Parameters and Antioxidant Components in Diabetic Rat Model

Abstract

Background: The aim of this study is to investigate the in vivo antidiabetic activity of Laurocerasus officinalis Roem. Because this fruit is used as antidiabetic natural products in Middle and Eastern Black Sea Reagon, Turkey. Methods: Ascorbic acid, lycopene, β-carotene and vitamin E contents of extract were determined. Also, GSH, nitrite-nitrate, ascorbic acid, MDA, catalase and lipid-linked sialic acid experiments were performed as in vivo trials. Result: The fresh and dried samples of taflan were found as rich sources of ascorbic acid (240.4 and 334.1 mg/100 g samples, respectively) and â-carotene (321.58 and 462.35 µg/100 g samples, respectively). However, lycopene and vitamin E contents in fruit not detected. The taflan has a positive effect (8.1%) on weight-loss of diabetic group (DLO). Moreover, taflan application had a pronounced effect on the blood glucose level decreasing (54.2%) after STZ application. Also, it regulated the MDA level (1.96 nmol/L) in diabetic rats according to diabetic group (2.41 nmol/L). Nitrite levels have been found as 1.92, 1.84, 1.97 and 2.02 ppm and nitrate levels as 6.91, 6.72, 9.29 and 11.46 ppm for the same samples, respectively. While ascorbic acid levels of blood serum samples were determined as 28.03, 29.47, 27.70 and 24.43 µg/mL, catalase levels were found as 0.604, 0.758, 0.479, 0.286 (mU/L), respectively. According to the obtained results, Laurocerasus officinalis Roem might have therapeutic antidiabetic effect, which suggest its bioactive components as candidate of natural pharmaceuticals.