Abstract
Sterol carrier protein X (SCP x) is a peroxisomal protein with both lipid transfer and thiolase activity. Treating with the fatty acid, lauric acid, induced SCP x mRNA levels in rat liver and in rat hepatoma H4IIE cells but enhanced protein levels of SCP x and the thiolase produced as a post-translational modification of SCP x were only seen in H4IIE cells. Further investigation revealed that the presence of insulin can mask lauric acid effects on the SCP x gene especially at the protein level. These data are in agreement with the findings that diabetes, a medical condition characterized by high levels of fatty acids in an insulin deficient environment, enhances the hepatic expression of SCP x .
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