LAUGHING SEIZURES- A RARE DISORDER IN PEDIATRIC PATIENTS

Abstract

Gelastic epilepsy or laughing seizures have been historically related to children with hypothalamic hamartomas. Gelastic seizures are rare; they are usually associated with other seizure types and can be restricted to a limited period during the evolution of an epileptic syndrome early-onset gelastic epilepsy, hypothalamic harmatoma, and precocious puberty syndrome. This condition typically results in a catastrophic epileptic encephalopathy, which is usually refractory to antiepileptic therapy, but in most cases, it is reversed by surgical excision, radiofrequency thermocoagulation, or gamma-knife surgery of the HH. Therefore, despite its rarity, this syndrome is of clinical relevance and an early diagnosis is important. Moreover, this review provides a model for the study of Gelastic epileptic mechanisms. Keywords: Laugh-induced seizure, Gelastic seizure, Parietal cortical dysplasia