Abstract
A diet containing Lathyrus odoratus seeds was administered to rats at a level which markedly inhibited the cross-linking of collagen yet which produced no aortic damage as a result of this. The biosynthesis, turnover, and tissue content of the various mucopolysaccharides in aorta, skin, and costal cartilage, was completely unaffected. A similar diet was administered to rabbits for a much longer time until aortic aneurysms and skeletal deformities were produced. At this time the ability of ear cartilage tissue to incorporate [ 14C]glucose in vitro into chondroitin sulfate was studied and no difference was seen between this tissue and that from control rabbits, whether or not β-aminopropionitrile (β-APN) was added to the medium. We propose that compounds which produce osteolathyrism have no effect on mucopolysaccharide metabolism per se and that the changes which have been described in the past are secondary to tissue injury brought about by long standing impairment of collagen fiber integrity.
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