Abstract
Mannich reaction is very important in organic chemistry, especially plays a very important role in the synthesis of drugs. In addition, Mannich base has widespread attention because of it is more significant and specific biological activity. Mannich reaction, diastereoselectivity Mannich reaction, enantioselective Mannich reaction and the application of Mannich reaction are introduced. Finally, the development aspect of this research is brought forward. Keywords Mannich reaction; Mannich base; catalyst; application; diastereoselectivity; enantioselective
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