Latest Advances in Gene Therapy in Management of Cystic Fibrosis Lung Disease, Literature Review

Abstract

Cystic fibrosis is an autosomal recessive disease that affects ion channels on epithelial cells. This leads to thicker and dysfunctional secretions. This can be evident when looking at the major symptoms of CF patients, which include recurrent respiratory tract infections and pancreatic insufficiency. The current management options for CF are either to manage the symptoms or modulate the existing defective genes. Gene therapy aims to correct dysfunctional genes as a way to cure the disease. We a