Lateralized impairment of the emotional enhancement of verbal memory in patients with amygdala–hippocampus lesion

Abstract

This study investigated amygdala–hippocampus’s functional asymmetry in the emotional modulation of memory for stories. Thirty-nine, right-handed, drug-resistant epilepsy patients who had been submitted to unilateral temporal lobectomy (19 left and 20 right) watched either an arousing or neutral version of a story presented audio-visually. The slide sequence was the same in the neutral and arousing version, the narratives were matched for structure and comprehensibility. The set and order of the 11 slide sequence were identical in both conditions. Free recall and recognition measures were taken 2 h after story presentation. Subjects in the TLE group who watched the arousing version recalled more details than the subjects who watched the neutral version (t(37)=3.4, p<.001) . The group who watched the arousing version recalled more details of the phase 2 of the story (t(37)=6.76, p<.001) . Scores in both conditions did not differ between control subjects and temporal lobectomy patients. When the right and left lesioned groups’ results were analyzed separately, it was observed that the two groups did not differ in their recall of the neutral version. The right lesioned group recalled more items of the arousal than the neutral version (Z=−3.55, p<.001) . However the left lesioned group did not show the memory enhancement for the emotional version, in this group it was only found an enhanced recall of the more pictorial emotional segment of the narrative (Z=−3.11, p<.001) . This illustrates that the right amygdala can influence retention of complex emotional stimuli with verbal and pictorial arousing properties. We concluded that an intact left amygdala–hippocampus is important for enhancement of memory related to emotionally arousing verbal material.