Lateralization of repetition effects in event-related potentials to words in left- and right-handed women

Abstract

In our previous event-related potential (ERP) study [A. Nowicka, I. Szatkowska, Memory-induced modulation of event-related potentials in frontal cortex of human subjects: a divided visual field study, Neurosci. Lett. 359 (2004) 171–174], word repetition effects in right-handed males were observed only in case of the direct stimulation of the left (competent) hemisphere. Since the left-handedness and the factor of female gender may determine the lateralization of verbal functions, the goal of the present study was to test the sensitivity of the ERP repetition effects to the visual field of word presentation in the group of left- and right-handed women. ERPs were recorded from symmetrical sites over the left and right hemisphere. Target words were presented in the left (LVF) or right (RVF) visual hemifield. Subjects’ were instructed to recognize the target word on a response card. A substantial portion of words was repeated twice. Words elicited different ERPs at frontal sites when presented the first and second times: ERPs were more positive to the repeated stimulus than to its first occurrence. However, in right-handed participants, repetition effects were only observed when target words were presented to the RVF whereas in left-handed participants, repetition effects were only observed when target words were presented to the LVF. These findings are indicative of the asymmetrical involvement of the two hemispheres in memory-induced modulation of brain activity related to verbal processing in left- and right-handed women.