Abstract
A novel technique for lateral resolution improvement in optical coherence tomography (OCT) is presented. The proposed method is based on lateral oversampling of the image. The locations and weights of multiple high spatial resolution sub-volumes are calculated using a Capon estimator assuming each contributes a weighted portion to the detected signal. This technique is independent of the delivery optics and the depth of field. Experimental results demonstrate that it is possible to achieve ~4x lateral resolution improvement which can be diagnostically valuable, especially in cases where the delivery optics are constrained to low numerical aperture (NA).
Highlights
The lateral resolution of Optical Coherence Tomography (OCT) images is fundamentally limited by the delivery optics
We present a new method for lateral resolution improvement which is independent of the focusing conditions and the depth of field
The experimental evaluation of the methods described above was performed on OCT images from a phantom of microspheres with an oversampling factor of 28
Summary
The lateral resolution of Optical Coherence Tomography (OCT) images is fundamentally limited by the delivery optics. A novel two-dimensional numerical method to achieve improved lateral resolution and a long measurement range was developed [8] This method is extremely sensitive to the phase stability of the measurements, which may be maintained during in vivo imaging where sample movement is unavoidable. We present a new method for lateral resolution improvement which is independent of the focusing conditions and the depth of field. It is based on lateral oversampling [13,14] and the estimation of the weighted contributions of multiple signals forming high spatial resolution sub-volumes, based on Capon estimation. Results from the implementation of this method on laterally oversampled OCT images have shown that it is possible to achieve lateral resolution improvement of about a factor of 4, greater than that achieved with any of the deconvolution approaches
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