Lateral Optical Binding of Stratified Biological Cells Induced by High-Order Bessel Beams

Abstract

Based on the generalized multi-particle Mie equation (GMM) and Electromagnetic Momentum (EM) theory, the lateral binding force (BF) exerted on stratified biological cells induced by an arbitrary polarized high-order Bessel beam (HOBB) is investigated with particular emphasis on the half-conical angle of the wave number components. The illuminating HOBB with arbitrary polarization angle is described in terms of beam shape coefficients (BSCs) within the framework of generalized Lorenz-Mie theories (GLMT). Different types of cells, including a real Chinese Hamster Ovary (CHO) cell and a lymphocyte which are respectively modeled by a coated and five-layered sphere, are studied. Numerical effects of various parameters such as beam polarization angles, incident wavelengths, particle sizes are numerically analyzed in detail. The observed dependence of the separation of optically bound particles on the incidence of HOBB is in agreement with earlier theoretical prediction. Accurate investigation of BF induced by HOBB could provide an effective test for further research on BF between more complex particles, which plays an important role in using optical manipulation on particle self-assembly.