Abstract
Dihydrostreptomycin was formulated as its pamoate salt as part of a search for a long-acting product. In dogs, an intramuscular injection of a cottonseed oil suspension of dihydro-streptomycin pamoate was absorbed more slowly than equivalent doses of dihydrostreptomycin sulfate suspended in cottonseed oil or dissolved in water. Pharmacokinetic studies suggest that plasma data can be described by the one-compartment open model, and that both salts are equally available.
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