Abstract
Neuropsychiatric symptoms (NPS) are prevalent in mild cognitive impairment (MCI) and dementia and are associated with accelerated clinical disease progression. 1 Peters ME Rosenberg PB Steinberg M et al. Neuropsychiatric symptoms as risk factors for progression from CIND to dementia: the Cache County Study. Am J Geriatr Psychiatry. 2013; 21: 1116-1124 Abstract Full Text Full Text PDF PubMed Scopus (94) Google Scholar Such symptoms also occur in cognitively unimpaired older adults, in whom they may be harbingers of cognitive decline. 2 Geda YE Roberts RO Mielke MM et al. Baseline neuropsychiatric symptoms and the risk of incident mild cognitive impairment: a population-based study. Am J Psychiatry. 2014; 171: 572-581 Crossref PubMed Scopus (200) Google Scholar Indeed, growing evidence suggests that depression, anxiety, and other late-life NPS may be risk factors or indicators for faster progression from cognitively normal status to MCI and dementia. 1 Peters ME Rosenberg PB Steinberg M et al. Neuropsychiatric symptoms as risk factors for progression from CIND to dementia: the Cache County Study. Am J Geriatr Psychiatry. 2013; 21: 1116-1124 Abstract Full Text Full Text PDF PubMed Scopus (94) Google Scholar , 2 Geda YE Roberts RO Mielke MM et al. Baseline neuropsychiatric symptoms and the risk of incident mild cognitive impairment: a population-based study. Am J Psychiatry. 2014; 171: 572-581 Crossref PubMed Scopus (200) Google Scholar , 3 Rosenberg PB Mielke MM Appleby BS et al. The associationof neuropsychiatric symptoms in MCI with incident dementia and Alzheimer disease. Am J Geriatr Psychiatry. 2013; 21: 685-695 Abstract Full Text Full Text PDF PubMed Scopus (210) Google Scholar
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