Abstract
Sputum colour (SC) is an accessible marker of underlying airway inflammation and along with other airway and systemic markers can potentially be utilised to aid management of COPD. Aims: This subanalysis aims to evaluate the relationship between SC, sputum and blood biomarkers, and isolated potentially pathogenic microorganisms (PPM) during exacerbations. Methods: We studied preliminary data from 127 COPD subjects (355 exacerbations over the first year) recruited into AERIS study (NCT01360398). SC was graded against a 5-colour sputum chart by trained laboratory staff. Patients reported change in SC (Y/N) via e-diary. Results: Using logistic regression and taking subjects effect into account we found that darker sputum colour reported by technicians was associated with higher likelihood of PPM presence (OR 2.80, p=0.001 95%CI 1.54 to 5.06). There was no significant association between patient reported change in SC and PPM presence (OR 1.51 p=0.353 95% CI 0.63 to 3.61). Correlation results are presented in the table below. Conclusion: SC was significantly associated with underlying airway neutrophilia and most systemic inflammatory markers. SC was significantly associated with the presence of PPM. SC objectively measured against a graded chart combined with other biomarkers of airway and systemic inflammation may be utilised to guide clinical management of COPD exacerbations.
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