Late Transition Metal-Mediated Formation of Carbon–Halogen Bonds

Abstract

This chapter reviews the synthesis of nonactivated aromatic halides assisted by late transition metal complexes. Although some of these reactions have been known for over half-a-century, there was a tremendous progress in the stoichiometric and catalytic applications of late transition metals in halogenation of aromatic compounds. Both nucleophilic and electrophilic halogenation pathways have been explored, resulting in practical methods for making aryl-halides. The chapter provides a metal-by-metal discussion of the above reactions, including the possible mechanisms of the metal-promoted formation of C-Halogen bonds.