Abstract
We analyzed patients treated after mastectomy with 7-MeV electron beam. The fractions were delivered twice-weekly over a five-week period for a time-dose fractionation (TDF) of 82. We observed an unacceptable incidence of late skin changes in follow-up. The degree of late skin changes did not correlate with the acute toxicity. The reasons for the observed late changes are unclear. Several mechanisms may be responsible. It is possible the fractionation schedule contributed to the observed changes. We encourage institutions using large, infrequent fractions to analyze their material for late tissue damage.
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