Abstract
10064 Background: Adult survivors of childhood NHL are at risk for chronic conditions likely underestimated by patient reported outcomes. Prevalence and severity based on direct clinical assessment are lacking. Methods: Clinical, laboratory, and performance-based evaluations were obtained on 200 adult survivors of pediatric NHL at St. Jude Children’s Research Hospital. Chronic conditions were graded per CTCAE criteria. Impaired physical function was defined as performance below the 10th percentile of normative data. Multivariable Poisson regression models were used to investigate associations [relative risk (RR), 95% confidence intervals (CI)] between patient characteristics, therapies, and clinical outcomes. Results: Survivors (66% male, 87% white) were a median age of 10 years (range 1-19) at diagnosis and 34 years (20-58) at evaluation. Forty-six (23%) received radiation to the brain, 69(35%) high dose methotrexate, and 161(81%) steroids. Most (93%) had ≥ 1 chronic condition, 77% ≥ 2 chronic conditions...
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