Late-onset affective and psychotic disorders: The challenge of disentangling neurodegenerative diseases from primary psychiatric disorders

Abstract

A proportion of patients with neurodegenerative dementia (DLB, FTD or AD) present with treatment-resistant affective disorder or psychosis and diagnosis is a challange. We study: the prevalence and type of neurodegenerative diseases among a sample of patients presenting with late-onset depression or psychosis followed longitudinally for two years and the cognitive differences between neurodegenerative diseases and PDD.