Abstract
Late Intrathecal Cell Therapy Increases Brain Glucose Metabolism and Improves the Long-Term Established Sequelae of Cerebral Hemorrhage
Highlights
The possibility of an increase in brain glucose metabolism after intrathecal administrations of autologous mesenchymal stromal cells (MSCs) has been recently reported, suggesting a role in the treatment of neurological disorders
After numerous preclinical studies and a growing experience in patients, there seems to be evidence of the usefulness of cell therapy in stroke, improving functional recovery [1,2,3]. These studies have generally been performed in acute phases, and the benefit has been attributed to the well-known properties of cell therapy, achieving neuroprotective effect or enhancing endogenous neurogenesis
Taking into account the importance of knowing the therapeutic window in which cell therapy can be useful in the treatment of stroke, in the past our group applied delayed cell therapy with Mesenchymal Stromal Cells (MSCs) after experimental cerebral hemorrhage in rodents, obtaining evidence that intracerebral administration of MSCs two months after brain hemorrhage can improve established neurological sequelae [4,5]
Summary
A 49-year-old female suffered from 2009 severe neurological sequelae after spontaneous intracerebral hemorrhage open to ventricle in the left frontoparietal region. She received 3 intrathecal administrations of 100 million autologous MSCs each three months, until a total dose of 300 million
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