Abstract
Chronic salt loading of female Wistar rats was produced by a gradual restriction of fluid intake to 2% NaCl. As judged by rate of loss of body weight and mean survival young mature rats were less affected than older rats, During a 2-month period of salt loading, 13 to 30% of the control rats died. Survivors of a single exposure to 1000 r of hypoxic whole-body x irradiation were tested by chronic salt loading 2 to 9 months later. Loss of weight was more rapid than in the controls, and all the rats died within 2 months. In both controls and irradiated rats on a salt loading regime, death was preceded by very high levels of serum Na, up to 200 meq/l. Although one-third of irradiated rats dying spontaneously in old age showed typical nephrosclerosis, morphologic renal disease was infrequent in both irradiated and control rats dying while on chronic salt load. (auth)
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