Abstract
Late effects after allogeneic hematopoietic cell transplantation with busulphan conditioning in 33 childhood leukemia survivors (1987-2013)
Highlights
After allogeneic hematopoietic cell transplantation for childhood leukemia, the pediatrician, and primarily the parents of the cured child, would like to know the number and the severity of the late effects (LE) expected at adulthood
We found a mean number of severe late effects of 1.1 per patient without any correlation with delay from allo-Hematopoietic Cell Transplantation (HCT), less than one third of the patients had at least 2 severe late effects and only 6% had 3 or more severe LE
Our results are close to that of Bernard et al who noted among 66 patients with BU conditioning a mean of 2.35 LE with an increased risk of overweight (n=20) and alopecia (n=10) [4]
Summary
After allogeneic hematopoietic cell transplantation (allo-HCT) for childhood leukemia, the pediatrician, and primarily the parents of the cured child, would like to know the number and the severity of the late effects (LE) expected at adulthood. With a median delay of 7.9 years after allo-HCT, noted that the mean number of late effects (any grade) increased to 5 in the cohort of patients treated with total body irradiation (TBI) conditioning vs 2.3 in the cohort of patients treated with busulphan conditioning (BU) [1]. The number of LE (any grade) after BU was 2.35 with an increased risk of overweight (OR=3.9) and alopecia (OR=11.2). Bresters et al confirmed the risk of alopecia in 16% of patients treated with BU [8]
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