Abstract
METHEMOGLOBIN (metHb), resulting from the oxidation of iron in hemoglobin from the ferrous state to ferric state, cannot bind oxygen and thereby leads to a displacement of the hemoglobin dissociation curve to the left. It can, therefore, impair tissue oxygen delivery. Methemoglobinemia, which is characterized by the presence of a higher-than-normal level of metHb, either can be congenital (due to Hb variants or deficiency of enzymes that convert metHb back to Hb) or acquired (caused by drugs or toxins 1 Trapp L. Will J. Acquired methemoglobinemia revisited. Dent Clin North Am. 2010; 54: 665-675 Abstract Full Text Full Text PDF PubMed Scopus (29) Google Scholar , 2 Umbreit J. Methemoglobin—It's not just blue: A concise review. Am J Hematol. 2007; 82: 134-144 Crossref PubMed Scopus (251) Google Scholar ).
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