Abstract
Possible biochemical changes in cholinergic systems were investigated in nine brain regions of rats kindled by daily amygdaloid stimulation. Choline acetyltransferase (CAT) activity in the kindled animals was significantly decreased bilaterally in the frontal cortex, amygdala, and hippocampus. No such bilateral changes were found in specific muscarinic cholinergic receptor binding. In the stimulated hemisphere, muscarinic cholinergic receptor binding was decreased in the frontal cortex but increased in the amygdala. In the nonstimulated hemisphere, that receptor binding increased in the pyriform cortex. These results imply persistent effects of amygdaloid kindling on cholinergic neurotransmission.
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