Abstract
Hand disinfection should be performed on the occasion of 5 separate moments during patient care, but some occasions are skipped. Can using hand antiseptics with residual effect reduce the problem of infection spread? We evaluated a 30-minute residual effect by different antiseptic products on endogenous and acquired microbiota. The products tested were 2% and 5% chlorhexidine, 1% and 10% iodine povidone, 60° n-propanol, 0.2% mecetronium+isopropanol, and 0.6% chlorhexidine+isopropanol+ 0.1% benzalconium chloride. The microorganisms identified were 3 ATCC and 9 multiresistant strains isolated from intensive care unit patients (used as acquired microbiota). Logarithmic (log10) reductions of the colony forming units obtained with each antiseptic product and for each microorganism were calculated via invivo (6 volunteers) and invitro tests. The better invivo and invitro products with a residual effect > 2 log10 after 30minutes on hands were 2%-5% chlorhexidine and 0.6% chlorhexidine+ isopropanol+ 0.1% benzalconium chloride. This reduction was significantly different (P<.01) from the other 4 antiseptics. This residual effect (> 2 log10) can be considered a self-disinfecting hand status in daily practice. Hand antiseptics used in hospitals must pass tests of residual efficacy (after 30minutes on acquired microbiota) showing a reduction > 2 log10 invivo and invitro. A good product can be the mixture of chlorhexidine+ alcohol+benzalconium chloride.
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