Abstract
Background Neuroblastoma (NB) is a heterogeneous tumor composed of mixed populations of neuroblastic, Schwannian, and gangliocytic cells. Procedure We examined the genetic lineage of Schwannian and neuroblastic cells in stage 4 NB using laser-capture microdissection (LCM) and allelic analysis of microsatellite markers of chromosomes 1p, 11q, and 14q. Results In 18 out of 19 cases, individual cell types exhibited the same allelotype. Conclusion Our results provide evidence that the majority of Schwannian and neuroblastic cells in stage 4 NB are of neoplastic origin, and support the hypothesis of a tumor stem cell capable of development along multiple lineages. Med. Pediatr. Oncol. 35: 534–537, 2000. © 2000 Wiley-Liss, Inc.
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