Abstract
We present experimental results of an in vivo study of laser-assisted photodissociation of carboxyhemoglobin (HbCO) in finger arterial blood under visible and near IR optical radiation. Arterial HbCO concentration was measured by a method of fingertip pulse oximetry. The light irradiating on the finger was provided by corresponding light emitting diodes (LED) at 15 wavelengths in the 400–940 nm spectral range. It is shown that there is a decrease in HbCO concentration in the blood under the influence of the transcutaneous laser irradiation. Three maxima (at 525, 600 and 850 nm) in the spectral range are observed, wherein the decrease in the HbCO concentration exceeds 50 %. The maximum value of the photodissociation of HbCO is observed at the 850 nm region. The obtained data correlate with the processes of light propagation in biological tissue. Irradiating HbCO at the spectra maximum, we measured a considerably high photodissociation yield of nearly 75%, which ensures high efficiency of photodecomposition of the HbCO in the blood. The obtained results can be used in the clinical phototherapy practice for effective treatment of carbon monoxide intoxication.
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