Abstract
Laminar flow in arteries causes streaming and uneven distribution of infused agents within the organ. This may lead to misinterpretation of experimental results and affect treatment outcomes. We monitor dynamical changes of superficial cortical blood flow in the rat kidney following different routes of administration of the vasoconstrictor angiotensin II. Our analysis reveals the appearance of large scale oscillations of the blood flow caused by inhomogeneous intra organ drug distribution.
Highlights
One of the problems with intra-arterial infusion of drugs is that the infused solution may stream preferentially to certain branches of the arterial tree and not be distributed uniformly in the tissue
In this paper we demonstrate the use of laser speckle flowmetry to monitor the effect of intra organ drug distribution on superficial cortical blood flow in the kidney
Since laser speckle microscopy provides full-field real-time imaging of superficial blood flow we address the following questions: (i) How does homogeneity of drug distribution depend on different types of injections? (ii) What are the effects of uneven drug distribution? and (iii) How are local flow changes correlated to integral changes of the renal blood flow?
Summary
One of the problems with intra-arterial infusion of drugs is that the infused solution may stream preferentially to certain branches of the arterial tree and not be distributed uniformly in the tissue. This issue is of clinical importance with regard to drug delivery to target organs [1,2,3,4]. Our group initiated the use of laser speckle flowmetry (LSF) to detect temporal and spatial flow changes on the kidney surface of anesthetized rats [8, 11]. Et al [12], using LSF on the surface of the rat kidney, analyzed oscillatory components in the blood perfusion during control conditions, enhanced autoregulation (L-NAME) and inhibited vasomotion (rho-kinase inhibitor Y-27632)
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