Abstract
This research presents the results of investigation of laser polarization fluorescence of biological layers (histological sections, cytological smears) in the task of diagnostics and differentiation of early stages of cancer: Dysplasia — cervical microinvasive carcinoma of cervix uteri. The analytical conditions of polarization-optimal probing of biological layers were determined basing on the model of linear birefringence and dichroism of birefringent (fibrillar, porphyrin) networks. The technique of polarization-variable laser autofluorescence was developed and experimentally tested. The objective criteria (statistical moments) of differentiation of histological sections autofluorescent images of endometrium biopsy and cytological smears of it mucous coat were defined. The operational characteristics (sensitivity, specificity, accuracy) of this technique were determined concerning the positions of probative medicine, and clinical efficiency.
Highlights
Biological tissues are structurally inhomogeneous optically anisotropic media with absorption
This research is focused on the development of polarization-variable technique of laser auto°uorescence of cervix uteri tissues in the task of objectication of diagnostics and di®erentiation of early stages of cervix uteri cancer
Histological sections of biopsy of cervix uteri endometrium were prepared according to standard technique on the freezing microtome
Summary
Biological tissues are structurally inhomogeneous optically anisotropic media with absorption. The step in development of methods of biological tissues optical diagnostics consists in successful combining of polarimetric and °uorescent methods.[25,26] The topical task in this direction is elaborating of new complex approaches concerning early diagnostics of pretumor changes of cervix uteri, which is the most widespread disease of women reproductive system. The traditional technique of diagnostics of cervix uteri cancer consists of the following operations: \cytological screening" — \colposcopy analysis" — \biopsy". Each of these stages is not perfect. This research is focused on the development of polarization-variable technique of laser auto°uorescence of cervix uteri tissues in the task of objectication of diagnostics and di®erentiation of early stages of cervix uteri cancer
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