Abstract

Posterior capsule opacification (PCO) is the most common complication following modern cataract surgery. PCO is caused by proliferation of lens epithelial cells (LECs) that remain in the capsular bag following cataract removal. Various methods for preventing PCO by LEC removal have been developed including pharmacological treatments and mechanical methods for LEC removal. A laser photolysis system has been developed for the removal of LECs from the lens capsular bag. A modified Nd:YAG handpiece has been evaluated in human cadaver eyes to document removal of LECs. In addition, extracellular matrix glycoproteins such as laminin and fibronectin, which may play a role in the development of PCO, were shown to be removed from the lens capsular bag by the photolysis system. Preliminary clinical studies have found that the laser was successful in removing the LECs from the anterior portion of the capsular bag with subsequent clear anterior and posterior capsules in the area of treatment for 2 years. In conclusion, the Nd:YAG laser photolysis system shows promise for prevention of PCO by removal of LECs as well as removal of adhesion glycoproteins.

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