Abstract
A laser ion source that will be installed on the new High Voltage Engineering (HVE) 5MV Singletron accelerator at the Columbia University Radiological Research Accelerator Facility (RARAF) will expand the linear energy transfer (LET) range available for irradiation experiments with mammalian cells. Through laser ablation the laser ion source can produce heavy ions with high charge states from a solid target; after acceleration, these ions will have sufficient energy to irradiate cells on a thin surface at atmospheric pressure. A high-power 100Hz pulsed Nd:YAG laser used with the laser ion source has produced aluminum ions with charge states greater than nine. Proper power management issues are important in obtaining the high charge states while protecting sensitive laser optics. We expect that the laser ion source will enable us to use ions from hydrogen to iron, providing an LET range of about 10–4500keV/μm for cell targets.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.