Abstract
A new possible method to produce a transdermal patch is proposed in this paper. The study refers to the pulsed laser deposition method (PLD) applied on turmeric target in order to obtain thin layers. Under high power laser irradiation of 532 nm wavelength, thin films containing curcuminoids were obtained on different substrates such as glass and quartz (laboratory investigation) and hemp fabric (practical application). Compared FTIR, SEM-EDS and LIF analyses proved that the obtained thin film chemical composition is mainly demethoxycurcumin and bisdemethoxycurcumin which is evidence that most of the curcumin from turmeric has been demethixylated during laser ablation. Silanol groups with known role into dermal reconstruction are evidenced in both turmeric target and curcuminoid thin films. UV–VIS reflection spectra show the same characteristics for all the curcuminoid thin films, indicating that the method is reproducible. The method proves to be successful for producing a composite material, namely curcuminoid transdermal patch with silanol groups, using directly turmeric as target in the thin film deposited by pulsed laser technique. Double layered patch curcuminoid—silver was produced under this study, proving compatibility between the two deposited layers. The silver layer added on curcuminoid-silanol layer aimed to increase antiseptic properties to the transdermal patch.
Highlights
Turmeric effects on human’s health have been intensively studied lately, after its benefits had been observed during the long time use as spice in food
The method proposed by this study aims to solve the problem of poor solubility of turmeric in various solvents that makes it less available to pharmaceutical purposes [12]
The turmeric powder was compressed by the same method, mixed with potassium bromide when the Fourier transform infrared spectroscopy (FTIR) analysis was performed, the resulting spectra describing exactly the target used for pulsed laser deposition method (PLD)
Summary
Turmeric effects on human’s health have been intensively studied lately, after its benefits had been observed during the long time use as spice in food. Extracted from turmeric, curcumin, along with the other curcuminoids, were found as carriers of curative effects for a long list of diseases such as anti-inflammatory including in rheumatoid arthritis, antioxidant, increase of brain-derived neurotrophic factor (BDNF), benefits against depression, [1,2]. Cyto-protective, anticancer properties and immunomodulating effect of turmeric have been proven [3,4] and its antimicrobial, antioxidant, and astringents properties recommend it for stomatology and generally, oral uses [5,6]. A turmeric protective effect against natural and chemically-induced toxicity has been reported [7]. The natural composite components would interact to provide a synergic effect for a highly efficiency in order to obtain the desired purpose
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