Abstract
Laser capture microdissection (LCM) is used to isolate minute amounts of tissue for subsequent proteomics analysis. An advantage of this technique is that a specific subset of cells or tissue structures can be isolated and enriched from surrounding material. Here, we describe a LCM-based method for the isolation of amyloid plaques from the Alzheimer's disease (AD) brain using fluorescence and nano liquid chromatography (nLC) mass spectrometry (MS) analysis. Using this approach, we detect ~600 proteins in ~250 AD amyloid plaques.
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