Abstract
Laser-assisted anastomosis of pigs' coronary arteries has been investigated using an Argon laser and a technique of applying an appropriate chromophore to the site of anastomosis. Remote infrared temperature measurements have shown that bonding was achieved at temperatures between 65 and 80°C corresponding to the collagen denaturation temperature and visual changes in the appearance of the tissue. Further laser irradiation produced carbonization and extensive tissue damage. Application of a chromophore at the site of anastomosis allowed a large reduction in the incident laser energy density. In end-to-end anastomosis, with only one supportive stay suture, bursting pressures of 90 to 310 mmHg (mean 203 mmHg) were achieved within a power range of 0.3 to 0.5 W with an exposure time of 50 to 210 s. Histological sections showed limited tissue damage but some variation in the vessel wall alignment which may explain variability in the mechanical strength. The laboratory studies have allowed us to optimize bonding conditions before embarking on animal tests.
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