Abstract
The combination of laser desorption and ablation with mass spectrometry has been, and will continue to be, a useful marriage of technologies. Quadrupole ion trap mass spectrometry, which has evolved from a simple mass selective detector for gas chromatography to a high performance analytical tool over the last decade, is being coupled more frequently with desorption sources, such as lasers and particle beams. The present work addresses a shortcoming of the use of laser sampling with quadrupole ion traps: laser ablation of samples directly within the storage volume of the trap can lead to suppression of the RF storage field, thereby reducing ion-trapping efficiency during the ionization event. A systematic examination of the phenomenon has been conducted and the advantages of selective injection or ionization methods, such as resonant laser ablation, for elimination of this problem are presented. © 1997 John Wiley & Sons, Ltd.
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