Laryngeal Mucormycosis

Abstract

Objectives: Report our experience with mucormycosis of the larynx, an extremely rare clinical entity. Methods: A single case of laryngeal mucormycosis was reviewed. Data and history reviewed include initial presentation, operative reports, operative photographs, pathology reports, outpatient clinic data, and follow-up reports. Results: In September of 2011, an individual presented to UAB with acute airway obstruction. An operative airway evaluation revealed mucosal necrosis and ischemia that on biopsy revealed non-septate hyphae consistent with mucor. Despite appropriate pharmacologic therapy, his disease progressed. Ultimately total laryngotracheal involvement prevented surgical cure. He later succumbed to pulmonary manifestations of his disease. Conclusions: Mucormycosis is an aggressive disease that requires multi-modality therapy and a high index of suspicion. Though the larynx is a rare subsite, the relative paucity of laryngotracheal blood supply makes mucor a diagnostic consideration in the immunocompromised patient.